https://nor-kleb.net/kleb-gap.php

KLEB-GAP

January 13, 2020

Klebsiella pneumoniae – a key driver in the global spread of antimicrobial resistance and a target for new approaches in diagnostics, surveillance and alternative therapeutics (KLEB-GAP)

The overall aim of the KLEB-GAP project is to explore Klebsiella pneumoniae (Kp) reservoirs using a first-in-kind One Health approach to develop new antimicrobial resistance diagnostics, innovative surveillance methods, and evaluate bacteriophages as treatment against multidrug resistant Kp. The project will explore the presence, persistence, and transmission of Kp and related mobile genetic elements (such as plasmids) and antimicrobial resistance determinants within and across human, animal, and marine reservoirs through advanced genomic and bioinformatic analyses of large prospectively collected samples (including the NOR-KLEB collections).

The project will provide new knowledge for

further development of global surveillance methodology to monitor the flow of Kp, mobile genetic elements and related antimicrobial resistance in humans and across sectors,

the development of new methods, beyond the state-of-art for diagnostics and surveillance of Kp-clonal lineages involved in antimicrobial resistance dispersion and pathogenicity, and

pre-clinical efficacy studies of bacteriophages as treatment of colonisation and infection by multidrug resistant Kp.

KLEB-GAP is coordinated by UiT – The Arctic University of Norway in close collaboration with Stavanger University Hospital (SUH). Arnfinn Sundsfjord (UiT) is the PI and Iren Löhr (SUH) co-PI. Morover, the Norwegian Veterinary Institute, the Institute of Marine Research and ACD Pharma are national partners. International partners are the Monash University in Melbourne, Karolinska Institutet in Stockholm, Queens University in Belfast and Institùt Pasteur in Paris, France. KLEB-GAP is funded by the Trond Mohn foundation (2019-2023). Read more here: https://mohnfoundation.no/amr-prosjekter-2/ (in Norwegian).

---